If you are aware of any Canadian research into ticks or tick-borne illnesses that should be included below, please send me an email and include the details. Please note that while summaries of the journal articles listed below are fairly universally accessible by the public, full text access often requires a fee and/or account.

Last updated: May 7, 2025.

2024
Title
MINNO: An Open Source Software for Refining Metabolic Networks and Investigating Complex Network Activity Using Empirical Metabolomics Data
Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain
Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1
2023
Title
Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape
DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice
Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data
2022
Title
The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete
VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force
2021
Title
The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature
2020
Title
Live Imaging
Strain-specific Joint Invasion and Colonization by Lyme Disease Spirochetes Is Promoted by Outer Surface Protein C
2019
Title
Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.
Changing of the guard: How the Lyme disease spirochete subverts the host immune response
2018
Title
A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat
Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline
Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair
2015
Title
Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein
2014
Title
Construction and characterization of a Borrelia burgdorferi strain with conditional expression of the essential telomere resolvase, ResT.
Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
2013
Title
Illuminating the roles of the Borrelia burgdorferi adhesins
Peaceful coexistence amongst Borrelia plasmids: Getting by with a little help from their friends?
Suggested Role for G4 DNA in Recombination Switching at the Antigenic Variation Locus of the Lyme Disease Spirochete.
2012
Title
Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity.
CSM Murray Award Lecture – Functional studies of the Lyme disease spirochete – from molecules to mice
2011
Title
HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete