Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

Author:

Kumar, D, Ristow, LC, Shi, M, Mukherjee, P, Caine, JA, Lee, WY, Kubes, P, Coburn, J, and Chaconas, G

Publication type:

Journal Article

Publication date:

2015-12

Journal/Series title:

PLos Pathog

Volume:

Issue:

URL:

http://www.ncbi.nlm.nih.gov/pubmed/26684456

Abstract:

Although integrin-binding proteins with diverse functions are encoded by a variety of bacterial pathogens, P66 is the first to have a documented and direct role in vascular transmigration. The emerging picture of vascular escape by the Lyme spirochete shows similarities, but distinct differences from leukocyte transmigration.