DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

Author:
Pfeifle, A, Raman, SNT, Lansdell, C, Zhang, W, Tamming, L, Cecillon, J, Laryea, E, Patel, D, Wu, J, Gravel, C, Frahm, G, Gao, J, Chen, W, Chaconas, G, Sauve, S, Rosu-Myles, M, Wang, L, Johnston, MJW, and Li, X
Publication type: 
Journal Article
Publication date: 
2023-03
Journal/Series title: 
Front Immunol.
Volume: 
14
URL: 
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1020134/full
Abstract: 

Overall, the results of this study provide support for the use of a DNA-LNP platform for the development of LD vaccines.