A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat

Author:

Castellanos, M, Verhey, TB, and Chaconas, G

Publication type:

Journal Article

Publication date:

2018-09

Journal/Series title:

Molecular Microbiology

Volume:

109

Issue:

URL:

https://www.ncbi.nlm.nih.gov/pubmed/29995993

Abstract:

Amplicon sequencing using PacBio long read technology and analysis of the data with our recently reported pipeline and VAST software showed that the system undergoes switching in mice in both linear and circular versions and that the presence of the hairpin does not seem to be crucial in the linear version, however it is required when the topology is circular.