Canadian Tick-borne Research 2010-Present

Please note that while summaries of the journal articles listed below are fairly universally accessible by members of the public, full text access often (though not always) requires a fee and/or account.

If you are aware of any Canadian research into ticks or tick-borne illnesses that should be included below, please send me an email and include whatever details you have.

Last updated: May 1, 2024

Found 22 results
Filters: Author is Chaconas G  [Clear All Filters]
2024
Mandwal A, Bishop SL, Castellanos M, Westlund A, Chaconas G, Davidsen J, and Lewis I, “MINNO: An Open Source Software for Refining Metabolic Networks and Investigating Complex Network Activity Using Empirical Metabolomics Data”, Anal Chem, vol. 96, no. 8, 2024.
2023
Tan X, Castellanos M, and Chaconas G, “Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape”, Microbiol Spectr, 2023.
Pfeifle A, Raman SNT, Lansdell C, Zhang W, Tamming L, Cecillon J, Laryea E, Patel D, Wu J, Gravel C, Frahm G, Gao J, Chen W, Chaconas G, Sauve S, Rosu-Myles M, Wang L, Johnston MJW, and Li X, “DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice”, Front Immunol., vol. 14, 2023.
Mandwal A, Bishop SL, Castellanos M, Westlund A, Chaconas G, Lewis I, and Davidsen J, “Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data”, bioRxiv, 2023.
2022
Castellanos M, Verhey TB, Goldstein M, and Chaconas G, “The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete”, Front Microbiol, vol. 13, 2022.
Tan X, Lin YP, Pereira MJ, Castellanos M, Hahn BL, Anderson P, Coburn J, Leong J, and Chaconas G, “VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force”, PLos Pathogen, vol. 18, no. 5, 2022.
2021
Tan X, Petri B, DeVinney R, Jenne CN, and Chaconas G, “The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature”, Mol Microbiol, 2021.
2020
Chaconas G, Moriarty TJ, Skare JT, and Hyde JA, “Live Imaging”, Curr Issus Mol Biol, vol. 42, pp. 385-408, 2020.
2019
Verhey TB, Castellanos M, and Chaconas G, “Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.”, Mol Microbiol., 2019.
Chaconas G, Castellanos M, and Verhey TB, “Changing of the guard: How the Lyme disease spirochete subverts the host immune response”, J Biol Chem, 2019.
2018
Verhey TB, Castellanos M, and Chaconas G, “Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline.”, Mol Microbiol., vol. 107, no. 1, 2018.
Verhey TB, Castellanos M, and Chaconas G, “Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.”, Cell Rep., vol. 23, no. 9, 2018.
Castellanos M, Verhey TB, and Chaconas G, “A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat.”, Mol Microbiol., vol. 109, no. 5, pp. 710-721, 2018.
2015
Kumar D, Ristow LC, Shi M, Mukherjee P, Caine JA, Lee WY, Kubes P, Coburn J, and Chaconas G, “Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein”, PLos Pathog, vol. 11, no. 12, 2015.
2014
Bandy NJ, Salman-Dilgimen A, and Chaconas G, “Construction and characterization of a Borrelia burgdorferi strain with conditional expression of the essential telomere resolvase, ResT.”, J Bacteriol., vol. 196, no. 13, 2014.
Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, and Kubes P, “Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.”, Proc Natl Acad Sci U S A, vol. 111, no. 38, 2014.
2013
Coburn J, Leong J, and Chaconas G, “Illuminating the roles of the Borrelia burgdorferi adhesins.”, Trends in Microbiology, vol. 21, no. 8, 2013.
Chaconas G and Morris SJ, “Peaceful coexistence amongst Borrelia plasmids: Getting by with a little help from their friends?”, Plasmid, vol. 17, no. 2, 2013.
Walia R and Chaconas G, “Suggested Role for G4 DNA in Recombination Switching at the Antigenic Variation Locus of the Lyme Disease Spirochete.”, PLoS ONE, vol. 8, no. 2, 2013.
2012
Lin T, Gao L, Zhang C, Odeh E, Jacobs MB, Coutte L, Chaconas G, Philipp MT, and Norris SJ, “Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity.”, PLoS ONE, vol. 7, no. 10, 2012.
Chaconas G, “ CSM Murray Award Lecture – Functional studies of the Lyme disease spirochete – from molecules to mice.”, Can J Microbiol, vol. 58, 2012.
2011
Salman-Dilgimen A, Hardy PO, Dresser AR, and Chaconas G, “HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete”, PloS One, vol. 6, no. 7, 2011.

Tick being held by tweezers Amblyomma americanum Tick in a vial Tick on blade of grass Tick displayed on finger Dermacentor andersoni