HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete

TitleHrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete
Publication TypeJournal Article
Year of Publication2011
AuthorsSalman-Dilgimen A, Hardy PO, Dresser AR, Chaconas G
JournalPloS One
Volume6
Start Page22168
Issue7
Keywordsbacteria, biology, borrelia, burgdorferi, disease, lyme
Abstract

In this work on the Lyme spirochete, B. burgdorferi, we show that a disruption of the hrpA gene, which encodes a putative RNA helicase, results in a complete loss in the ability of the spirochetes to infect mice by needle inoculation.

URLhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022168
DOI10.1371/journal.pone.0022168