DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

TitleDNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice
Publication TypeJournal Article
Year of Publication2023
JournalFront Immunol.
Volume14
Start Page1020134
Date Published03/2023
AuthorsPfeifle A, Raman SNT, Lansdell C, Zhang W, Tamming L, Cecillon J, Laryea E, Patel D, Wu J, Gravel C, Frahm G, Gao J, Chen W, Chaconas G, Sauve S, Rosu-Myles M, Wang L, Johnston MJW, Li X
Abstract

Overall, the results of this study provide support for the use of a DNA-LNP platform for the development of LD vaccines.
URLhttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1020134/full