HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete

Author:

Salman-Dilgimen, A, Hardy, PO, Dresser, AR, and Chaconas, G

Publication type:

Journal Article

Publication date:

2011-01

Journal/Series title:

PloS One

Volume:

Issue:

URL:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022168

Abstract:

In this work on the Lyme spirochete, B. burgdorferi, we show that a disruption of the hrpA gene, which encodes a putative RNA helicase, results in a complete loss in the ability of the spirochetes to infect mice by needle inoculation.