Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease

Author:

Khan, FM, Allehebi, ZO, Shabi, Y, Davis, IRC, LeBlanc, J, Lindsay, LR, and Hatchette, TF

Publication type:

Journal Article

Publication date:

2022-06

Journal/Series title:

Open Forum Infect Dis

Volume:

Issue:

URL:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297310/

Abstract:

The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early infection compared with the standard 2-tier algorithm while retaining high specificity in a region with a high incidence of LD.