Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution

Author:

Jarosz, AC, and Badawi, A

Publication type:

Journal Article

Publication date:

2019-01

Journal/Series title:

Inflamm Res.

Volume:

Issue:

URL:

https://www.ncbi.nlm.nih.gov/pubmed/30121835

Abstract:

Lyme disease or Lyme borreliosis (LB) is the commonest vector-borne disease in the North America. It is an inflammatory disease caused by the bacterium Borrelia burgdorferi. The role of the inflammatory processes mediated by prostaglandins (PGs), thromboxanes and leukotrienes (LTs) in LB severity and symptoms resolution is yet to be elucidated. We aim to systematically review and evaluate the role of PGs and related lipid mediators in the induction and resolution of inflammation in LB.