Lyme Disease in Canada

NMDA receptor (NMDAR) encephalitis was initially described by Dalmau et al. [1] and is associated to a constellation of symptoms such as psychosis, memory deficits, seizures, abnormal movements, and autonomic dysfunction. In many patients, these autoantibodies occur in the setting of underlying tumor (teratomas), but in the remainder of patients, the immunopathogenesis remains unclear. Recent reports suggest that viral infections may trigger NMDAR [2], leading to speculation that mechanisms such as molecular mimicry and/or bystander activation may play a role.