Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen

Author:

Javid, A, Zlotnikov, N, Pětrošová, H, Tang, TT, Zhang, Y, Bansal, AK, Ebady, R, Parikh, M, Glogauer, M, Moriarty, TJ, Mijhgan, A, Kim, YR, Sosa, MS, Sun, C, and

Publication type:

Journal Article

Publication date:

2016-06

Journal/Series title:

PLoS One

Volume:

Issue:

URL:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920391/

Abstract:

The present study investigated the impact of sustained obesity-independent hyperglycemia in mice on bacterial clearance, inflammatory pathology and neutrophil responses to B. burgdorferi. These data suggest that investigating the effects of comorbid conditions such as diabetes on outcomes of B. burgdorferi infections in humans may be warranted.