Analyses of human immune responses to Francisella tularensis identify correlates of protection

Author:

Lindgren, H, Eneslatt, K, Golovliov, I, Gelhaus, C, and Sjöstedt, A

Publication type:

Journal Article

Publication date:

2023-09

Journal/Series title:

Frontiers in Immunology

Section:

Microbial Immunology

Volume:

Issue:

URL:

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238391/full

Abstract:

Francisella tularensis is the etiological agent of the potentially severe infection tularemia. An existing F: tularensis vaccine, the live vaccine strain (LVS), has been used to protect at-risk personnel, but it is not licensed in any country and it has limited efficacy. Therefore, there is a need of a new, efficacious vaccine. The aim of the study was to perform a detailed analysis of the characteristics of the human immune response to F. tularensis, since this will generate crucial knowledge required to develop new vaccine candidates.