Neuroinvasion of emerging and re-emerging arboviruses: A scoping review

TitleNeuroinvasion of emerging and re-emerging arboviruses: A scoping review
Publication TypeJournal Article
Year of Publication2024
JournalSAGE Open Med
Date Published05/2024
AuthorsSrichawla BS, Manan MR, Kipkorir V, Dhali A, Diebel S, Sawant T, Zia S, Carrion-Alvarez D, Suteja RC, Nurani K, Gaman MA
Keywordsarboviruses, chikungunya virus, dengue virus, Japanese encephalitis virus, Mayaro virus, neuroinvasion, Powassan virus, St. Louis encephalitis virus, tick-borne encephalitis virus, West Nile virus, Zika virus, zoonosis

A total of 171 records were included. A wide array of neurological manifestations can occur most frequently, including parkinsonism, encephalitis/encephalopathy, meningitis, flaccid myelitis, and Guillain-Barré syndrome. Magnetic resonance imaging of the brain often reveals subcortical lesions, sometimes with diffusion restriction consistent with acute ischemia. Vertical transmission of arbovirus is most often secondary to the Zika virus. Neurological manifestations of congenital Zika syndrome, include microcephaly, failure to thrive, intellectual disability, and seizures. Cerebrospinal fluid analysis often shows lymphocytic pleocytosis, elevated albumin, and protein consistent with blood-brain barrier dysfunction.