Exploring the impact of Anaplasma phagocytophilum on colonization resistance of Ixodes scapularis microbiota using network node manipulation

TitleExploring the impact of Anaplasma phagocytophilum on colonization resistance of Ixodes scapularis microbiota using network node manipulation
Publication TypeJournal Article
Year of Publication2024
JournalCurr Res Parasitol Vector Borne Dis
Volume5
Date Published04/2024
AuthorsAbuin-Denis L, Piloto-Sardinas E, Maitre A, Wu-Chuang A, Mateos-Hernandez L, Obregon D, Corona-Gonzalez B, Fogaca AC, Palinauskas V, Azelyte J, Rodriguez-Mallon A, Cabezas-Cruz A
KeywordsColonization resistance, Community assembly, tick-borne pathogens, ticks
Abstract

Our findings revealed that infection with A. phagocytophilum does not significantly alter the overall microbial diversity in ticks. Despite a decrease in the number of nodes and connections within the microbial networks of infected ticks, certain core microbes remained consistently interconnected, suggesting a functional role. The network of infected ticks showed a heightened vulnerability to node removal, with smaller LCC and longer APL, indicating reduced resilience compared to the network of uninfected ticks. Interestingly, adding nodes to the network of infected ticks led to an increase in LCC and a decrease in APL, suggesting a recovery in network robustness, a trend not observed in networks of uninfected ticks. This improvement in network robustness upon node addition hints that infection with A. phagocytophilum might lower ticks' resistance to colonization, potentially facilitating further microbial invasions. We conclude that the compromised colonization resistance observed in tick microbiota following infection with A. phagocytophilum may facilitate co-infection in natural tick populations.

URLhttps://www.sciencedirect.com/science/article/pii/S2667114X24000086?via%3Dihub