A diagnostic classifier for gene expression-based identification of early Lyme disease

TitleA diagnostic classifier for gene expression-based identification of early Lyme disease
Publication TypeJournal Article
Year of Publication2022
JournalCommun Med (Lond)
Volume2
Start Page92
Date Published07/2022
AuthorsServellita V, Bouquet J, Rebman AW, Yang T, Samayoa E, Miller S, Stone M, Lanteri M, Busch MP, Tang P, Morshed MG, Soloski MJ, Aucott JN, Chiu CY
KeywordsBacterial host response, Bacterial infection, Diagnostic markers, RNA sequencing, Targeted resequencing
Abstract

We identify a 31-gene Lyme disease classifier (LDC) panel that can discriminate between early Lyme patients and controls, with 23 genes (74.2%) that have previously been described in association with clinical investigations of Lyme disease patients or in vitro cell culture and rodent studies of Borrelia burgdorferi infection. Evaluation of the LDC using an independent test set of samples from 63 subjects yields an overall sensitivity of 90.0%, specificity of 100%, and accuracy of 95.2%. The LDC test is positive in 85.7% of seronegative patients and found to persist for ≥3 weeks in 9 of 12 (75%) patients.

URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9306241/