Dermatological and Genital Manifestations of Lyme Disease Including Morgellons Disease

TitleDermatological and Genital Manifestations of Lyme Disease Including Morgellons Disease
Publication TypeJournal Article
Year of Publication2021
AuthorsMiddelveen MJ, Haggblad JS, Lewis J, Robichaud GA, Martinez RM, Shah JS, Du Cruz I, Fesler MC, Stricker RB
JournalClin Cosmet Investig Dermatol.
Volume14
Start Page425
Pagination425-436
Date Published05/2021
Keywordsborrelia burgdorferi, erythema migrans, Lyme disease, Morgellons disease, spirochetes, tickborne disease
Abstract

Although the erythema migrans (EM) skin rash is traditionally considered a hallmark of Lyme disease, other dermatological manifestations of the tickborne disease are less well known. We describe a 49-year-old woman with erosive genital ulcerations, secondary EM rashes and jagged skin lesions associated with Lyme disease. The skin rashes exhibited fibers characteristic of Morgellons disease. Molecular testing confirmed the presence of Borrelia DNA in both vaginal culture and serum specimens. In further studies on a secondary EM lesion containing filaments, Gömöri trichrome staining revealed the presence of collagen in the filaments, while Dieterle and anti-Borrelia immunostaining revealed intracellular and extracellular Borrelia organisms. Intracellular staining for Borrelia was also observed in lymphocytic infiltrates. Lyme disease may present with a variety of genital lesions and dermatological manifestations including Morgellons disease. Careful evaluation is required to determine the presence of Borrelia organisms associated with these dermopathies.

URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110212/