|Title||Analyses of human immune responses to Francisella tularensis identify correlates of protection|
|Publication Type||Journal Article|
|Year of Publication||2023|
|Authors||Lindgren H, Eneslatt K, Golovliov I, Gelhaus C, Sjöstedt A|
|Keywords||F. tularensis, human correlates of protection, immune response, memory cells, vaccination|
Francisella tularensis is the etiological agent of the potentially severe infection tularemia. An existing F: tularensis vaccine, the live vaccine strain (LVS), has been used to protect at-risk personnel, but it is not licensed in any country and it has limited efficacy. Therefore, there is a need of a new, efficacious vaccine. The aim of the study was to perform a detailed analysis of the characteristics of the human immune response to F. tularensis, since this will generate crucial knowledge required to develop new vaccine candidates.