Pharmacokinetics of imidocarb dipropionate in white‐tailed deer (Odocoileus virginianus) after single intramuscular administration

TitlePharmacokinetics of imidocarb dipropionate in white‐tailed deer (Odocoileus virginianus) after single intramuscular administration
Publication TypeJournal Article
Year of Publication2019
AuthorsMilnes EL, Delnatte P, Woodbury M, Hering A, Lee S, Smith DA, Nemeth NM, Gu Y, Gehring R, Johnson R
JournalJ Vet Pharmacol and Therap
Volume00
Start Page1
Pagination1-5
Date Published2019
Keywordsbabesia, Cervid babesiosis, white-tailed deer
Abstract

This study was designed to investigate the pharmacokinetics of imidocarb, a carbanilide derivative, in white‐tailed deer (Odocoileus virginianus). The pharmacokinetic properties of a single intramuscular (IM) dose of imidocarb were determined in 10 deer. A single IM injection of 3.0 mg/kg imidocarb dipropionate was administered, and blood samples were collected prior to, and up to 48 hr after imidocarb administration. Plasma imidocarb concentrations were determined by high‐performance liquid chromatography with ultraviolet detection. The disposition of plasma imidocarb was best characterized by a two‐compartment open model.

URLhttps://onlinelibrary.wiley.com/doi/10.1111/jvp.12760