Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis

TitleEfficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis
Publication TypeJournal Article
Year of Publication2019
AuthorsVogt NA, Sargent JM, MacKinnon MC, Versluis AM
JournalJ Vet Intern Med.
Volume33
Issue1
Date Published01/2019
Abstract

Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%.
Based on the quantitative synthesis of results from challenge studies, vaccinated dogs are less likely to develop clinical signs after exposure to B. burgdorferi compared to unvaccinated dogs. These results should be interpreted with caution, however, as several shortcomings related to quality and study design were identified. Future studies should focus on larger sample sizes in field conditions.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/30511365