Chagas' Cardiomyopathy and Lyme Carditis: Lessons Learned From Two Infectious Diseases Affecting the Heart

TitleChagas' Cardiomyopathy and Lyme Carditis: Lessons Learned From Two Infectious Diseases Affecting the Heart
Publication TypeJournal Article
Year of Publication2020
AuthorsYeung C, Medoza I, Echeverria LE, Baranchuk A
JournalTrends Cardiovasc Med .
Volume2020 May 3
Start PageS1050
PaginationS1050-1738(20)30058-X
Date Published05/2020
Abstract

Chagas' disease and Lyme disease are two endemic, vector-borne zoonotic infectious diseases that impact multiple organ systems, including the heart. Chagas' cardiomyopathy is a progressive process that can evolve into a dilated cardiomyopathy and heart failure several decades after the acute infection; in contrast, although early-disseminated Lyme carditis has been relatively well characterized, the sequelae of Lyme disease on the heart are less well-defined. A century of research on Chagas' cardiomyopathy has generated compelling data for pathophysiological models, evaluated the efficacy of therapy in large randomized controlled trials, and explored the social determinants of health impacting preventative measures. Recognizing the commonalities between Chagas' disease and Lyme disease, we speculate on whether some of the lessons learned from Chagas' cardiomyopathy may be applicable to Lyme carditis.

URLhttps://www.sciencedirect.com/science/article/abs/pii/S105017382030058X?via%3Dihub